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Monday, August 3, 2020 | History

4 edition of Endothelium-derived factors and vascular functions found in the catalog.

Endothelium-derived factors and vascular functions

proceedings of the Fourth International Symposium on Endothelium-Derived Factors, Tokyo, 7-9 December, 1993

by International Symposium on Endothelium-Derived Factors (4th 1993 Tokyo, Japan)

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Published by Excerpta Medica in Amsterdam, New York .
Written in English

    Subjects:
  • Vascular endothelium -- Molecular aspects -- Congresses.,
  • Endothelins -- Congresses.,
  • Nitric oxide -- Physiological effect -- Congresses.,
  • Cell adhesion molecules -- Congresses.,
  • Cellular signal transduction -- Congresses.,
  • Endothelium-Derived Relaxing Factor -- congresses.,
  • Vasoconstrictor Agents -- congresses.,
  • Vasodilator Agents -- congresses.,
  • Endothelium, Vascular -- physiology -- congresses.

  • Edition Notes

    Includes bibliographical references and index.

    Statementeditor, Tomoh Masaki.
    SeriesInternational congress series ;, no. 1051
    ContributionsMasaki, Tomoh.
    Classifications
    LC ClassificationsQP88.45 .I58 1993
    The Physical Object
    Paginationxi, 258 p. :
    Number of Pages258
    ID Numbers
    Open LibraryOL1092485M
    ISBN 100444816690
    LC Control Number94016819

    REVIEW Sex differences in vascular function: implication of endothelium-derived hyperpolarizing factor Inmaculada C Villar, Adrian J Hobbs and Amrita Ahluwalia1 Department of Pharmacology, University College London, Medical Sciences Building, Gower Street, London WC1E 6BT, UK. Effects of Extra Virgin Olive Oil and Apples Enriched-Dark Chocolate on Endothelial Progenitor Cells in Patients with Cardiovascular Risk Factors: A Randomized Cross-Over Trial. Felice F, Francini A, Domenici V, Cifelli M, Belardinelli E, Sebastiani L, Cantini C, Di Stefano R. Felice F, et al. Antioxidants (Basel). Apr 4;8(4) doi:

    Endothelium is a single layer of squamous endothelial cells that line the interior surface of blood vessels, and lymphatic vessels. The endothelium forms an interface between circulating blood or lymph in the lumen and the rest of the vessel wall. Endothelial cells form the barrier between vessels and tissue and control the flow of substances and fluid into and out of a tissue. and vasoconstrictor substances, termed endothelium-derived relaxing factor (EDRF) and endothelium-derived contracting factor (EDCF), respectively. The ability of the endothelium to control the under-lying vascular smooth muscle appears to be an ancestral property of these cells, emerging early in evolution (see Reference 2). This brief review sum-.

    The endothelium consists of a single layer of cells that serves as a barrier between blood and tissues and actively participates in the regulation of vascular tone and function (1). The influence of the endothelium on blood flow in arterioles and capillaries is modulated by the synthesis and release of a number of endothelial-derived relaxing and constricting substances such as nitric . In the past, endothelium was thought to be only a mechanical barrier. Today, endothelium is known to be a tissue regulating vascular tone, cell growth and the interaction between the leukocytes, thrombocytes and the vessel wall. It also synthesizes growth factors and thrombo-regulatory molecules and .


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Endothelium-derived factors and vascular functions by International Symposium on Endothelium-Derived Factors (4th 1993 Tokyo, Japan) Download PDF EPUB FB2

Endothelium-derived relaxing factor (EDRF) is an endogenous vasodilator that endothelial cells produce and subsequently release in response to various changes in normal physiologic as well as pathophysiologic changes. EDRF causes vascular smooth muscle to relax, as it activates soluble guanylate cyclase and subsequently increases cyclic guanylate monophosphate in vascular Author: Yasaman Pirahanchi, Kristen N.

Brown. Endothelium-Derived Hyperpolarizing Factor. Endothelium-derived hyperpolarizing factor is an important vasodilator in the microcirculation and acts by opening K+ channels to allow for K+ efflux, hyperpolarization, and vascular smooth muscle relaxation.

From: Vascular Medicine: A Companion to Braunwald's Heart Disease (Second Edition), Endothelium-Derived Hyperpolarizing Factor and Vascular Function Article (PDF Available) in Cardiology Research and Practice (1) August with. Thus, the EETs are endothelium-derived hyperpolarizing factors mediating a portion of the relaxations to acetylcholine, bradykinin, shear stress, and cyclic stretch and regulate vascular.

The Endothelium book. Modulator of Cardiovascular Function. By Thomas F. Luscher, Paul M. Vanhoutte. Edition 1st Edition.

First Published eBook Published 15 April Pub. location Boca Raton. Imprint CRC Press. Endothelium-Derived Relaxing Factor. With Thomas F.

Lüscher, Author: Thomas F. Lüscher, Paul M. Vanhoutte. The vascular endothelium is a distributed organ which in humans has a surface of more than m 2 and in brain approximates the surface area of a tennis court [1, 2].Vascular endothelium has many important functions including regulation of vascular tone, molecular exchange between blood and tissue compartments, hemostasis and signaling for the immune.

Cyclooxygenase-dependent Endothelium-derived Contracting Factors 4. Endothelium-derived Hyperpolarising Factor 5. Regulation of Blood Cell Function by Endothelial Cells 6. Hypertension 7. Endothelial Control of Vascular Tone in Chronic Heart Failure 8.

Hypercholesterolaemia, Atherosclerosis and the NO Synthase Pathway 9. Endothelial Function in. EDHF function may involve the participation of mediators, including several diffusible factors and non-diffusible factors, (e.g., conduction of hyperpolarization via myoendothelial gap junctions).

Indeed, in several vessels, cyclic adenosine 3,5-monophosphate (cAMP) facilitates EDHF responses by enhancing electrotonic conduction via gap junctions. These substances, known as endothelium-derived contracting factors (EDCF) or endothelium-derived relaxing factor (EDRF), can modify the vascular smooth muscle tone directly, acting on smooth muscle cells, or indirectly, by altering sympathetic transmission.

Nevertheless, when endothelium integrity and/or function is compromised, such. The role of ET as one of the most potent endothelium-derived vasoconstrictors is now complemented with a newly discovered role in vascular relaxation. The transcription of the ET genes in endothelial cells leads to the formation of preproET and big ET, which are further metabolized by ET converting enzymes into ET-1, -2, -3 and -4 isoforms.

Abstract. The endothelium-dependent regulation of vascular tone is predominantly by four major players: nitric oxide (NO), prostaglandin I 2 (PGI 2), endothelium-derived hyperpolarizing factor (EDHF), and endothelin-1 (ET-1).The former three are vasodilators, while ET-1 is a potent vasoconstrictor.

ISBN: OCLC Number: Description: xi, pages: illustrations ; 25 cm. Contents: Part 1 Endothelium-derived relaxing and constricting factors: interactions of superoxide and hydrogen peroxide with nitric oxide and EDRF in the regulation of vascular tone, R.F.

Furchgott et al; regulation of vascular endothelial cell function. It has been observed that several age-associated changes in the endothelium-derived factors are responsible for plaque formation in the arteries.

Importantly, endothelin (ET), a vascular endothelium-derived growth factor was found to be significantly increased in the aged endothelium [60,61,62].

ET mainly acts through its receptors ET-A and ET. The endothelium releases a variety of factors which can affect vascular tone. Endothelium-derived relaxing factor or nitric oxide is a very potent vasodilator and inhibitor of platelet function.

Its release has been demonstrated in a variety of human blood vessels. In most human vascular preparations, prostacyclin does not significantly contribute to the endothelium.

ENDOTHELIUM-DERIVED RELAXING FACTORS (EDRFS) Vascular endothelial cells play pivotal roles in maintaining cardiovascular homeostasis. The endothelium provides not only a physical barrier between the vessel wall and lumen, but also performs a critical function for the maintenance of blood pressure by releasing vasorelaxing factors and vasocontracting factors.

In vascular diseases, endothelial dysfunction is a systemic pathological state of the with acting as a semi-permeable membrane, the endothelium is responsible for maintaining vascular tone and regulating oxidative stress by releasing mediators, such as nitric oxide, prostacyclin and endothelin, and controlling local angiotensin-II activity.

The endothelium plays important roles in modulating vascular tone by synthesizing and releasing an array of endothelium-derived relaxing factors, including vasodilator prostaglandins, NO, and endothelium-dependent hyperpolarization (EDH) factors, as well as endothelium-derived contracting factors.

1,2 Such redundant mechanisms, like endogenous hyperglycemic. Experts offer detailed reviews on specific topics that address these roles of the endothelium: diffusion barrier, blood-brain barrier, regulator of capillary permeability, metabolic function (uptake and enzymatic destruction), conversion of vasoactive products, production of prostanoids, production and release of endothelium-derived relaxing Reviews: 1.

Introduction. Endothelial function refers to a multitude of physiological processes of the vascular endothelium that maintain healthy homeostasis of the vascular wall and may be used as a “barometer” of the injury/repair inflicted by multiple environmental and genetic factors [1–3].Vascular endothelial dysfunction is associated with a reduction in nitric oxide (NO).

Endothelium-derived relaxing factor (EDRF) is a name for a substance Robert F. Furchgott discovered had the eponymous properties. Today, it is firmly established this substance is nitric oxide (NO). Endothelium produces NO which then diffuses to the vascular smooth muscle tissue, although there seems to be evidence that vasodilation may also be of neuronal origin, rather.

Summary. Endothelial cells can release both relaxing and contracting substances. The former include prostacyclin, endothelium-derived relaxing factor (EDRF, which most likely is nitric oxide, or a nitrosoderivative releasing nitric oxide, derived from 1-arginine), and endothelium-derived hyperpolarizing factor (EDHF, which possibly is a labile metabolite of arachidonic .ISBN: OCLC Number: Description: 1 online resource ( pages) Contents: Book Cover; Title; Contents; Foreword; Contributors; Acknowledgements; Endothelial Nitric Oxide; The Endothelin System: Physiology; Cyclooxygenase-dependent Endothelium-derived Contracting Factors; Endothelium-derived Hyperpolarizing Factor; Regulation of Blood Cell Function.

Endothelium derived hyperpolarising factor (EDHF) is one of the three endothelium-derived relaxing factors (EDRFs), others being nitric oxide (NO) and prostacyclin (PGI2).

EDHF as the name implies, hyperpolarizes the vascular smooth muscle cells, causing them to relax and produce vasodilatation.